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weighting - passing drug that puzzle out like Ozempic can help oneself users disgorge pounds . Now , a unexampled cogitation suggest the medications could also aid multitude with alcohol usage disorder .
The inquiry , published Nov. 13 in the journalJAMA Psychiatry , tote up to a growingbody of workhinting these drug could help mass superintend drug and alcohol habituation .
In the study , investigator used data from more than 227,000 people in Sweden ’s patient data point registry , a national database of wellness records . The field of study ’s discipline were diagnose withalcohol use disorderbetween 2006 and 2021 . Among these , 4,321 people used semaglutide , the drug brand under the names Ozempic and Wegovy , and 2,509 people used liraglutide , another drug in the same social class . broadly speaking , these drug are called GLP-1 agonists because they mimic a hormone called GLP-1 thathelps regulate appetency and hunger .
The analysis base that the people using the drug were less likely to be hospitalise for job linked to alcohol function disorderliness , such as intoxication and pulling out symptoms like craze , than the patients who were n’t using the drugs . Semaglutide use was connect with a 36 % lower risk and liraglutide with a 28 % lower danger .
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Furthermore , the endangerment of hospital care due toanysubstance use disorder was 32 % lower in those occupy semaglutide , while liraglutide was affiliate with a 22 % low-down risk .
The researchers also looked at naltrexone , a drug okay to treat opioid and alcohol employment disorder . They chance it was associated with a 14 % reduction in the risk of hospitalization insurance for issue related to alcoholic drink and substance use .
" One of the most salient determination was that GLP-1 medications had a low peril than intoxicant - utilisation disorderliness medicine we use , " study conscientious objector - authorMarkku Lähteenvuo , a docent of forensic psychiatry at the University of Eastern Finland and Niuvanniemi Hospital , secern Live Science .
That say , Lähteenvuo underline that this form of study ca n’t once and for all show that the drug instantly treat a person ’s addiction . " These are association , and we take to verify them in clinical trials , " he said .
Still , he added , " the issue sizes were pretty big , so we are bright that these results are existent . "
Lorenzo Leggio , clinical director of the National Institute on Drug Abuse Intramural Research Program in Baltimore , said the work is " an interesting study that adds to the get evidence " that GLP-1 agonists could help treat inebriant economic consumption disorder and addiction in ecumenical . “It ’s important to note that alcohol use disorderliness and addiction are leading reason of hospitalization insurance , morbidity , and mortality , " Leggio , who was not involved in the study , told Live Science in an email . " This subject area inquire of import outcomes ( hospitalization ) that are very relevant from a clinical and public wellness viewpoint — another crucial strong suit of the study . "
A growing body of work
Lähteenvuo and his fellow worker are n’t the first to spot the link between GLP-1 drugs and dependence .
" A few long time ago , there was quite a buzz about these medications , and clinicians noticed their patients seemed to be reducing their alcohol intake , " he said . " It was kind of a chance determination . "
Since then , early research in the lab and some tangible - world study have supported this observation . Studieson miceandratsfound that semaglutide reduced the rodents ' binge booze installment and dependence on alcohol , after they ’d been provided with inebriant for some meter . In addition , some observational studies in humans — including one write Wednesday ( Nov. 26 ) in the journalJAMA web Open — have found that GLP-1 agonists were link up to low alcoholic drink utilisation in multitude with inebriant addiction .
And it ’s not just alcohol — previous study found a liaison between Ozempic - corresponding drugs and a low-down risk ofopioid overdoseandcannabis - utilization disorderrelapse .
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These late finding " offer the first real Bob Hope for the treatment of substance use disorder in decades,“Patricia " Sue " Grigson , chair of the Department of Neural and Behavioral sciences at Penn State College of Medicine , told Live Science in an electronic mail .
Still , Grigson and Leggio noted that clinical trials are postulate to show that the drug are in reality drive this change in addictive behaviors . The safety of using the drugs in this circumstance also ask to be confirmed , Grigson added .
" These clinical trials are being conducted , and some have been fill out , " Grigson state . The emerging data is promising , but " we must look pass completion of further work to make steadfast close , " she added .
This article is for informational purposes only and is not mean to offer aesculapian advice .
Ever wonder whysome multitude ramp up muscleman more easily than othersorwhy freckles come out in the sun ? Send us your question about how the human body works tocommunity@livescience.comwith the subject personal line of credit " Health Desk Q , " and you may see your question answered on the website !
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