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Women who apply some types of hormonal birth control condition and common painkillers callednonsteroidal anti - inflammatory drugs(NSAIDs ) at the same prison term may have a slightly increase risk of developing blood coagulum , new enquiry indicate .
In an observational subject area of 2 million women in Denmark published Wednesday ( Sept. 6 ) in the journalThe BMJ , researchers found that those who used NSAIDs at the same time as hormonal contraceptive method had an increase risk of develop blood clots in their veins , a potentially disabling or deathly experimental condition known asvenous thromboembolism(VTE ) . nonsteroidal anti-inflammatory let in drugs like Nuprin , Naprosyn and diclofenac .
According to the study, women who used certain “high risk” contraceptives, such as estrogen-and-progestin patches or vaginal rings, alongside NSAIDs were at the greatest risk of developing blood clots.
The study authors emphasized that , even among women using the gamy - risk contraceptive method alternative studied , the absolute jeopardy of VTE they honor was still comparatively gloomy — around 0.02 % of women in the highest - risk category . Still , they say the findings could facilitate inform wellness aid provider who are give notice patient role on which drugs may be most suited for them .
" consider the millions of woman exposed to these drug class , it is of course of interest , in a public wellness matter , to subjugate the risk of thrombosis [ blood clots ] in accompanying substance abuser of these two drug classes,“Dr . Amani Meaidi , lead source of the study and a postdoctoral researcher at the University of Copenhagen , told Live Science in an e-mail .
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In preceding studies , hormonal contraceptivesandNSAIDshave separately been linked to an increased risk of developing VTE . However , there has been picayune enquiry into whether using both at the same time could exacerbate this risk .
In the new study , research worker looked at the aesculapian record of 15- to 49 - yr - old women living in Denmark between 1996 and 2017 who had never had a blood coagulum , cancer , infertility treatment or surgery to have their uterus removed . They give chase hoi polloi ’s prescription for hormonal giving birth control and nonsteroidal anti-inflammatory drug using Denmark ’s National Registry of Medicinal Product Statistics . In all , more than 529,000 char used hormonal contraception and NSAIDs at the same time , with the most mutual NSAIDs being ibuprofen , diclofenac and naproxen .
The team categorize different types of hormonal contraceptive method into risk horizontal surface base on early studies that investigated the risk of ancestry clot in multitude who engage them . " eminent - risk " prophylactic equipment included combinedestrogen and progestin patches , vaginal mob , and pill hold 50 micrograms of estrogen . Combined oral contraceptivesandmedroxyprogesterone injections(Depo - Provera ) were deemed " intermediate risk , " andprogestin - only tablets(often called " minipills " ) , implants and hormonal intrauterine gadget were take " humbled " or " no risk . "
They find that using NSAIDs alone was linked to a slightly increased risk of blood clots , and that the danger was passably amplified when a sensitive - to gamey - risk hormonal contraceptive was added .
The combined risk is higher in women who also used eminent - peril contraception than in those who used medium- or low - risk varieties . For woman who did n’t use hormonal contraception , for every 100,000 who used an NSAID for a calendar week , the squad estimated that an spare four would develop a blood coagulum than if they did n’t habituate nonsteroidal anti-inflammatory drug . This number remains about the same for woman using nonsteroidal anti-inflammatory drug with down in the mouth - risk contraceptives , but it jumps to 11 for those using average - endangerment options and to 23 for adult female on high - risk of exposure contraceptives .
" This potentially paint a picture a synergetic drug interaction between these two drug class , " Meaidi say . However , in the composition , her and her atomic number 27 - author mention that " further research is warranted to determine the potential existence and mechanics of such drug interaction . "
The subject authors did foreground several limitation of the research . For instance , they ’re missing information on smoke and obesity rate among those studied , which may have affected the finding . Nor did they think wash or ethnicity , which caninfluence someone ’s riskof developing blood clots .
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Also , because this was an observational study , it does not show that either drug class , alone or meld , directly causes rip clots .
Dr. Andrew Kaunitz , a prof of obstetrics and gynaecology at the University of Florida who was not involved in the inquiry , also said it was possible that an takings calledprotopathic biasmay explicate the findings . This full term describes when a drug is prescribe to do by the initial symptom of a disease that has n’t yet been name .
" Use of NSAIDs by reproductive eld woman might reflect ahead of time ( not yet diagnose ) conditions , such aslupusorrheumatoid arthritis , conditions which themselves are associated with an high-flown risk of infection of coagulum , " Kaunitz told Live Science in an email .
When deliberate the risk of stemma clots tied to hormonal contraception , Kaunitz state it ’s important to keep that risk in context . " It is significant to keep in mind that the condition which contraceptive method prevents , notably pregnancy , is associated with a much higher risk of lineage clot than any contraceptive , " he said .
This article is for informational purposes only and is not meant to offer medical advice .
